Identification of DBC1 as a transcriptional repressor for BRCA1

BACKGROUND: DBC1/KIAA1967 (deleted in breast cancer 1) is a putative tumour-suppressor gene cloned from a heterozygously deleted region in breast cancer specimens. Caspase-dependent processing of DBC1 promotes apoptosis, and depletion of endogenous DBC1 negatively regulates p53-dependent apoptosis t...

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Detalhes bibliográficos
Main Authors: Hiraike, H, Wada-Hiraike, O, Nakagawa, S, Koyama, S, Miyamoto, Y, Sone, K, Tanikawa, M, Tsuruga, T, Nagasaka, K, Matsumoto, Y, Oda, K, Shoji, K, Fukuhara, H, Saji, S, Nakagawa, K, Kato, S, Yano, T, Taketani, Y
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2010
Assuntos:
Genetics and Genomics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2844029/
https://ncbi.nlm.nih.gov/pubmed/20160719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6605577
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