Dissection of Structure and Function of the N-Terminal Domain of Mouse DNMT1 Using Regional Frame-Shift Mutagenesis

Deletion analysis of mouse DNMT1, the primary maintenance methyltransferase in mammals, showed that most of the N-terminal regulatory domain (amino acid residues 412–1112) is required for its enzymatic activity. Although analysis of deletion mutants helps to identify regions of a protein sequence re...

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Bibliografiske detaljer
Main Authors: D'Aiuto, Leonardo, Marzulli, Marco, Mohan, K. Naga, Borowczyk, Ewa, Saporiti, Federica, VanDemark, Andrew, Chaillet, J. Richard
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2010
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2843745/
https://ncbi.nlm.nih.gov/pubmed/20352123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0009831
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