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Synergistic Signals for Natural Cytotoxicity Are Required to Overcome Inhibition by c-Cbl
To safeguard from “permissive” NK cell reactivity towards target cells, activation by receptors such as NKG2D and 2B4 includes a requirement for synergistic coactivation. How synergy occurs is not known. Synergistic phosphorylation of PLC-γ2, Ca(2+) mobilization, and degranulation triggered by NKG2D...
שמור ב:
| Main Authors: | , , , , |
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| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
2010
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2843589/ https://ncbi.nlm.nih.gov/pubmed/20189481 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2010.02.004 |
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