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A tale of tails: sialidase is key to success in a model of phage therapy against K1-capsulated Escherichia coli

Prior studies treating mice infected with Escherichia coli O18:K1:H7 observed that phages requiring the K1 capsule for infection (K1-dep) were superior to capsule-independent (K1-ind) phages. We show that three K1-ind phages all have low fitness when grown on cells in serum whereas fitnesses of four...

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Détails bibliographiques
Auteurs principaux: Bull, J. J., Vimr, E. R., Molineux, I. J.
Format: Artigo
Langue:Inglês
Publié: 2009
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2843586/
https://ncbi.nlm.nih.gov/pubmed/20006993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2009.11.040
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