Therapeutic Potential of Proteasome Inhibition in Duchenne and Becker Muscular Dystrophies

Duchenne muscular dystrophy (DMD) and its milder allelic variant, Becker muscular dystrophy (BMD), result from mutations of the dystrophin gene and lead to progressive muscle deterioration. Enhanced activation of proteasomal degradation underlies critical steps in the pathogenesis of the DMD/BMD dys...

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Detalhes bibliográficos
Main Authors: Gazzerro, Elisabetta, Assereto, Stefania, Bonetto, Andrea, Sotgia, Federica, Scarfì, Sonia, Pistorio, Angela, Bonuccelli, Gloria, Cilli, Michele, Bruno, Claudio, Zara, Federico, Lisanti, Michael P., Minetti, Carlo
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2010
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2843476/
https://ncbi.nlm.nih.gov/pubmed/20304949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.090468
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