Iowa Variant of Familial Alzheimer’s Disease : Accumulation of Posttranslationally Modified AβD23N in Parenchymal and Cerebrovascular Amyloid Deposits

Mutations within the amyloid-β (Aβ) sequence, especially those clustered at residues 21-23, which are linked to early onset familial Alzheimer’s disease (AD), are primarily associated with cerebral amyloid angiopathy (CAA). The basis for this predominant vascular amyloid burden and the differential...

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Bibliografiske detaljer
Main Authors: Tomidokoro, Yasushi, Rostagno, Agueda, Neubert, Thomas A., Lu, Yun, Rebeck, G. William, Frangione, Blas, Greenberg, Steven M., Ghiso, Jorge
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Investigative Pathology 2010
Fag:
Regular Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2843474/
https://ncbi.nlm.nih.gov/pubmed/20228223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.090636
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