Dicer1 and miR-219 Are Required for Normal Oligodendrocyte Differentiation and Myelination

To investigate the role of microRNAs in regulating oligodendrocyte (OL) differentiation and myelination, we utilized transgenic mice in which microRNA processing was disrupted in OL precursor cells (OPCs) and OLs by targeted deletion of Dicer1. We found that inhibition of OPC-OL miRNA processing dis...

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Detalhes bibliográficos
Main Authors: Dugas, Jason C., Cuellar, Trinna L., Scholze, Anja, Ason, Brandon, Ibrahim, Adiljan, Emery, Ben, Zamanian, Jennifer L., Foo, Lynette C., McManus, Michael T., Barres, Ben A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2843397/
https://ncbi.nlm.nih.gov/pubmed/20223197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2010.01.027
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