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The effects of the CapZ peptide (TRTK-12) binding to S100B-Ca(2+) as examined by NMR and X-ray crystallography
Structure-based drug design is underway to inhibit the S100B-p53 interaction as a strategy for treating malignant melanoma. X-ray crystallography was used here to characterize an interaction between Ca(2+)-S100B and a target, TRTK-12, which binds to the p53 binding site on S100B. The structures of C...
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| Autors principals: | , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2010
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2843395/ https://ncbi.nlm.nih.gov/pubmed/20053360 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2009.12.057 |
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