Simian immunodeficiency virus (SIV) infection of infant rhesus macaques as a model to test antiretroviral drug prophylaxis and therapy: oral 3'-azido-3'-deoxythymidine prevents SIV infection.

The prophylactic and therapeutic properties of 3'-azido-3'-deoxythymidine (AZT) against simian immunodeficiency virus (SIV) infection were tested in four 3-month-old rhesus macaques. The infant monkeys were inoculated intravenously with a low dose (1 to 10 100% animal infectious doses) of...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Van Rompay, K K, Marthas, M L, Ramos, R A, Mandell, C P, McGowan, E K, Joye, S M, Pedersen, N C
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 1992
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC284339/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1489181/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.36.11.2381
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