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Nuclear Factor κB- and Specificity Protein 1-dependent p53-mediated Bi-directional Regulation of the Human Manganese Superoxide Dismutase Gene

Tumor suppressor p53 is known to activate certain sets of genes while suppressing others. However, whether p53 can both activate and suppress the same gene is unclear. To address this question, concentration-dependent p53 effect on the manganese superoxide dismutase (MnSOD) gene was investigated. By...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Dhar, Sanjit K., Xu, Yong, St. Clair, Daret K.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2010
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2843232/
https://ncbi.nlm.nih.gov/pubmed/20061391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.060715
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