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G9a and Glp Methylate Lysine 373 in the Tumor Suppressor p53

The tumor suppressor p53 is regulated by numerous post-translational modifications. Lysine methylation has recently emerged as a key post-translational modification that alters the activity of p53. Here, we describe a novel lysine methylation site in p53 that is carried out by two homologous histone...

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Hlavní autoři: Huang, Jing, Dorsey, Jean, Chuikov, Sergei, Zhang, Xinyue, Jenuwein, Thomas, Reinberg, Danny, Berger, Shelley L.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2010
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2843213/
https://ncbi.nlm.nih.gov/pubmed/20118233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.062588
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