DNA Methylation-mediated Down-regulation of DNA Methyltransferase-1 (DNMT1) Is Coincident with, but Not Essential for, Global Hypomethylation in Human Placenta

The genome of extraembryonic tissue, such as the placenta, is hypomethylated relative to that in somatic tissues. However, the origin and role of this hypomethylation remains unclear. The DNA methyltransferases DNMT1, -3A, and -3B are the primary mediators of the establishment and maintenance of DNA...

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Detalhes bibliográficos
Main Authors: Novakovic, Boris, Wong, Nick C., Sibson, Mandy, Ng, Hong-Kiat, Morley, Ruth, Manuelpillai, Ursula, Down, Thomas, Rakyan, Vardhman K., Beck, Stephan, Hiendleder, Stefan, Roberts, Claire T., Craig, Jeffrey M., Saffery, Richard
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
DNA And Chromosomes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2843208/
https://ncbi.nlm.nih.gov/pubmed/20071334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.064956
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