Cyclin-dependent Kinase-9 Is a Component of the p300/GATA4 Complex Required for Phenylephrine-induced Hypertrophy in Cardiomyocytes

A zinc finger protein GATA4 is one of the hypertrophy-responsive transcription factors and forms a complex with an intrinsic histone acetyltransferase, p300. Disruption of this complex results in the inhibition of cardiomyocyte hypertrophy and heart failure in vivo. By tandem affinity purification a...

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Autori principali: Sunagawa, Yoichi, Morimoto, Tatsuya, Takaya, Tomohide, Kaichi, Shinji, Wada, Hiromichi, Kawamura, Teruhisa, Fujita, Masatoshi, Shimatsu, Akira, Kita, Toru, Hasegawa, Koji
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2010
Soggetti:
Gene Regulation
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2843206/
https://ncbi.nlm.nih.gov/pubmed/20081228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.070458
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