The dietary compound curcumin inhibits p300 histone acetyltransferase activity and prevents heart failure in rats

Hemodynamic overload in the heart can trigger maladaptive hypertrophy of cardiomyocytes. A key signaling event in this process is nuclear acetylation by histone deacetylases and p300, an intrinsic histone acetyltransferase (HAT). It has been previously shown that curcumin, a polyphenol responsible f...

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Главные авторы: Morimoto, Tatsuya, Sunagawa, Yoichi, Kawamura, Teruhisa, Takaya, Tomohide, Wada, Hiromichi, Nagasawa, Atsushi, Komeda, Masashi, Fujita, Masatoshi, Shimatsu, Akira, Kita, Toru, Hasegawa, Koji
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Clinical Investigation 2008
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2248328/
https://ncbi.nlm.nih.gov/pubmed/18292809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI33160
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