Metabolic disposition and pharmacokinetics of the antiviral agent 6-methoxypurine arabinoside in rats and monkeys.

The metabolism and pharmacokinetics of 6-methoxypurine arabinoside (ara-M), a potent and selective inhibitor of varicella-zoster virus, were investigated in rats and monkeys. In Long Evans rats, orally administered [8-14C]ara-M (10 mg/kg) was well absorbed but extensively metabolized to hypoxanthine...

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Vydáno v:	Antimicrob Agents Chemother
Hlavní autoři:	Burnette, T C, Koszalka, G W, Krenitsky, T A, De Miranda, P
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Microbiology (ASM) 1991
Témata:	Research Article
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC284305/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1929259/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.35.6.1165
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