Separating the Wheat from the Chaff: Unbiased Filtering of Background Tandem Mass Spectra Improves Protein Identification

Only a small fraction of spectra acquired in LC-MS/MS runs matches peptides from target proteins upon database searches. The remaining, operationally termed background, spectra originate from a variety of poorly controlled sources and affect the throughput and confidence of database searches. Here,...

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Bibliographische Detailangaben
Hauptverfasser: Junqueira, Magno, Spirin, Victor, Balbuena, Tiago Santana, Waridel, Patrice, Surendranath, Vineeth, Kryukov, Grigoriy, Adzhubei, Ivan, Thomas, Henrik, Sunyaev, Shamil, Shevchenko, Andrej
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2842913/
https://ncbi.nlm.nih.gov/pubmed/18558732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/pr800140v
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