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Dinucleotide Weight Matrices for Predicting Transcription Factor Binding Sites: Generalizing the Position Weight Matrix

BACKGROUND: Identifying transcription factor binding sites (TFBS) in silico is key in understanding gene regulation. TFBS are string patterns that exhibit some variability, commonly modelled as “position weight matrices” (PWMs). Though convenient, the PWM has significant limitations, in particular t...

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Bibliografiske detaljer
Hovedforfatter: Siddharthan, Rahul
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2842295/
https://ncbi.nlm.nih.gov/pubmed/20339533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0009722
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