Negative feedback control of HIF-1 through REDD1-regulated ROS suppresses tumorigenesis

The HIF family of hypoxia-inducible transcription factors are key mediators of the physiologic response to hypoxia, whose dysregulation promotes tumorigenesis. One important HIF-1 effector is the REDD1 protein, which is induced by HIF-1 and which functions as an essential regulator of TOR complex 1...

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Bibliografiske detaljer
Main Authors: Horak, Peter, Crawford, Andrew R., Vadysirisack, Douangsone D., Nash, Zachary M., DeYoung, M. Phillip, Sgroi, Dennis, Ellisen, Leif W.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2010
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2842042/
https://ncbi.nlm.nih.gov/pubmed/20176937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0907705107
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