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Inhibition of Chemokine Receptor Expression on Uveal Melanomas by CXCR4 siRNA and Its Effect on Uveal Melanoma Liver Metastases
PURPOSE: To determine whether blocking the expression of the chemokine receptor CXCR4 using siRNA inhibits chemotactic responses of human uveal melanoma cells to liver-derived factors and prevents liver metastases. METHODS: Human uveal melanoma cells were transfected with CXCR4 siRNA or control siRN...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2841954/ https://ncbi.nlm.nih.gov/pubmed/19553629 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.09-3804 |
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