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Dose-dependent induction of distinct phenotypic responses to Notch pathway activation in mammary epithelial cells

Aberrant activation of Notch receptors has been implicated in breast cancer; however, the mechanisms contributing to Notch-dependent transformation remain elusive because Notch displays dichotomous functional activities, promoting both proliferation and growth arrest. We investigated the cellular ba...

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Detalhes bibliográficos
Main Authors: Mazzone, Marco, Selfors, Laura M., Albeck, John, Overholtzer, Michael, Sale, Sanja, Carroll, Danielle L., Pandya, Darshan, Lu, Yiling, Mills, Gordon B., Aster, Jon C., Artavanis-Tsakonas, Spyros, Brugge, Joan S.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2841923/
https://ncbi.nlm.nih.gov/pubmed/20194747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1000896107
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