A modified hTERT Promoter-directed Oncolytic Adenovirus Replication with Concurrent Inhibition of TGFβ Signaling for Breast Cancer Therapy

Our laboratory is interested to develop oncolytic adenoviral vectors that can be administered systemically for the treatment of breast cancer. To restrict viral replication in breast tumor cells, we have constructed mhTERTAd.sTβRFc, a 01/07 based adenoviral vector expressing the soluble form of TGFβ...

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Detalhes bibliográficos
Main Authors: Hu, Zebin, Robbins, John S., Pister, Amanda, Zafar, M. Behzad, Zhang, Zhen-Wei, Gupta, Janhavi, Lee, K. Jessica, Neuman, Kam, Yun, Chae-Ok, Guise, Theresa, Seth, Prem
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2841698/
https://ncbi.nlm.nih.gov/pubmed/19798122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cgt.2009.72
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