Ergosterol biosynthesis inhibition by the thiocarbamate antifungal agents tolnaftate and tolciclate.

The thiocarbamate antimycotics tolnaftate and tolciclate blocked sterol biosynthesis in fungal cells and cell extracts, with accumulation of squalene. This point of action was confirmed by the direct inhibition of microsomal squalene epoxidase from Candida albicans. There was no inhibition of other...

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Vydáno v:	Antimicrob Agents Chemother
Hlavní autoři:	Ryder, N S, Frank, I, Dupont, M C
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Microbiology (ASM) 1986
Témata:	Research Article
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC284167/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3524433/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.29.5.858
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