Ergosterol biosynthesis inhibition by the thiocarbamate antifungal agents tolnaftate and tolciclate.

The thiocarbamate antimycotics tolnaftate and tolciclate blocked sterol biosynthesis in fungal cells and cell extracts, with accumulation of squalene. This point of action was confirmed by the direct inhibition of microsomal squalene epoxidase from Candida albicans. There was no inhibition of other...

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Εκδόθηκε σε:	Antimicrob Agents Chemother
Κύριοι συγγραφείς:	Ryder, N S, Frank, I, Dupont, M C
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	American Society for Microbiology (ASM) 1986
Θέματα:	Research Article
Διαθέσιμο Online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC284167/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3524433/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.29.5.858
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