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Mitochondrial autophagy as a compensatory response to PINK1 deficiency

Macroautophagy (hereafter, autophagy) plays a critical role in maintaining cellular homeostasis by degrading protein aggregates and dysfunctional/damaged organelles. We recently reported that silencing the recessive familial Parkinson disease gene encoding PTEN-induced kinase 1 (PINK1) leads to neur...

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Détails bibliographiques
Auteurs principaux: Cherra, Salvatore J., Dagda, Ruben K., Tandon, Anurag, Chu, Charleen T.
Format: Artigo
Langue:Inglês
Publié: 2009
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2841445/
https://ncbi.nlm.nih.gov/pubmed/19786829
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