An integrative genomics approach to infer causal associations between gene expression and disease

A key goal of biomedical research is to elucidate the complex network of gene interactions underlying complex traits such as common human diseases. Here we detail a multistep procedure for identifying potential key drivers of complex traits that integrates DNA-variation and gene-expression data with...

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Detalhes bibliográficos
Main Authors: Schadt, Eric E, Lamb, John, Yang, Xia, Zhu, Jun, Edwards, Steve, GuhaThakurta, Debraj, Sieberts, Solveig K, Monks, Stephanie, Reitman, Marc, Zhang, Chunsheng, Lum, Pek Yee, Leonardson, Amy, Thieringer, Rolf, Metzger, Joseph M, Yang, Liming, Castle, John, Zhu, Haoyuan, Kash, Shera F, Drake, Thomas A, Sachs, Alan, Lusis, Aldons J
Formato: Artigo
Idioma:Inglês
Publicado em: 2005
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2841396/
https://ncbi.nlm.nih.gov/pubmed/15965475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng1589
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