Sodium valproate-induced congenital cardiac abnormalities in mice are associated with the inhibition of histone deacetylase

BACKGROUND: Valproic acid, a widely used anticonvulsant drug, is a potent teratogen resulting in various congenital abnormalities. However, the mechanisms underlying valproic acid induced teratogenesis are nor clear. Recent studies indicate that histone deacetylase is a direct target of valproic aci...

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Autori principali: Wu, Gang, Nan, Changlong, Rollo, Johnathon C, Huang, Xupei, Tian, Jie
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2010
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2841099/
https://ncbi.nlm.nih.gov/pubmed/20219112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1423-0127-17-16
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