Tie1-Tie2 interactions mediate functional differences between angiopoietin ligands

The endothelial specific receptor tyrosine kinase Tie2, and the orphan receptor tyrosine kinase, Tie1, are essential for endothelial cell proliferation, migration, and survival during angiogenesis. Despite their considerable similarity, experiments with Tie1 or Tie2 deficient mice highlight distinct...

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Main Authors: Seegar, Tom C.M., Eller, Becca, Tzvetkova-Robev, Dorothea, Kolev, Momchil V., Henderson, Scott C., Nikolov, Dimitar B., Barton, William A.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2841065/
https://ncbi.nlm.nih.gov/pubmed/20227369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2010.02.007
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