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12-Lipoxygenase Products Reduce Insulin Secretion and β-Cell Viability in Human Islets
Context: Inflammation is increasingly recognized as an important contributing factor in diabetes mellitus. Lipoxygenases (LOs) produce active lipids that promote inflammatory damage by catalyzing the oxidation of linoleic and arachidonic acid, and LO is expressed in rodent and human islets. Little i...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The Endocrine Society
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2840856/ https://ncbi.nlm.nih.gov/pubmed/20089617 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2009-1102 |
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