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Nuclear Targeting of Cyclin-Dependent Kinase 2 Reveals Essential Roles of Cyclin-Dependent Kinase 2 Localization and Cyclin E in Vitamin D-Mediated Growth Inhibition

1,25-Dihydroxyvitamin D(3) (1,25-(OH)(2)D(3)), inhibits proliferation of a variety of cell types including adenocarcinoma of the prostate. We have previously shown that 1,25-(OH)(2)D(3) increases the stability of the cyclin-dependent kinase inhibitor p27(KIP1), decreases cyclin-dependent kinase 2 (C...

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Detalhes bibliográficos
Main Authors: Flores, Omar, Wang, Zhengying, Knudsen, Karen E., Burnstein, Kerry L.
Formato: Artigo
Idioma:Inglês
Publicado em: The Endocrine Society 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2840684/
https://ncbi.nlm.nih.gov/pubmed/20147522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2009-1116
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