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Sustained delivery of thermostabilized chABC enhances axonal sprouting and functional recovery after spinal cord injury
Chondroitin sulfate proteoglycans (CSPGs) are a major class of axon growth inhibitors that are up-regulated after spinal cord injury (SCI) and contribute to regenerative failure. Chondroitinase ABC (chABC) digests glycosaminoglycan chains on CSPGs and can thereby overcome CSPG-mediated inhibition. B...
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| Главные авторы: | , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2009
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2840440/ https://ncbi.nlm.nih.gov/pubmed/19884507 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0905437106 |
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