Sustained delivery of thermostabilized chABC enhances axonal sprouting and functional recovery after spinal cord injury

Chondroitin sulfate proteoglycans (CSPGs) are a major class of axon growth inhibitors that are up-regulated after spinal cord injury (SCI) and contribute to regenerative failure. Chondroitinase ABC (chABC) digests glycosaminoglycan chains on CSPGs and can thereby overcome CSPG-mediated inhibition. B...

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Bibliographische Detailangaben
Hauptverfasser: Lee, Hyunjung, McKeon, Robert J., Bellamkonda, Ravi V.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2009
Schlagworte:
Regenerative Medicine Special Feature
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2840440/
https://ncbi.nlm.nih.gov/pubmed/19884507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0905437106
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