A mutation of Ikbkg causes immune deficiency without impairing degradation of IκBα

Null alleles of the gene encoding NEMO (NF-κB essential modulator) are lethal in hemizygous mice and men, whereas hypomorphic alleles typically cause a syndrome of immune deficiency and ectodermal dysplasia. Here we describe an allele of Ikbkg in mice that impaired Toll-like receptor signaling, lymp...

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Detalhes bibliográficos
Main Authors: Siggs, Owen M., Berger, Michael, Krebs, Philippe, Arnold, Carrie N., Eidenschenk, Celine, Huber, Christoph, Pirie, Elaine, Smart, Nora G., Khovananth, Kevin, Xia, Yu, McInerney, Gerald, Karlsson Hedestam, Gunilla B., Nemazee, David, Beutler, Bruce
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2840324/
https://ncbi.nlm.nih.gov/pubmed/20133626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0915098107
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