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Disruption of the Lcn2 gene in mice suppresses primary mammary tumor formation but does not decrease lung metastasis

Based largely on studies in xenograft models, lipocalin-2 (Lcn2) has been implicated in the progression of multiple types of human tumors, including breast cancer. Here we examine the role of Lcn2 in mammary tumorigenesis and lung metastasis using an in vivo molecular genetics approach. We crossed a...

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Main Authors: Berger, Thorsten, Cheung, Carol C., Elia, Andrew J., Mak, Tak W.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2010
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2840296/
https://ncbi.nlm.nih.gov/pubmed/20133630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1000101107
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