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Universal distribution of protein evolution rates as a consequence of protein folding physics
The hypothesis that folding robustness is the primary determinant of the evolution rate of proteins is explored using a coarse-grained off-lattice model. The simplicity of the model allows rapid computation of the folding probability of a sequence to any folded conformation. For each robust folder,...
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| Autors principals: | , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2010
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2840281/ https://ncbi.nlm.nih.gov/pubmed/20133769 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0910445107 |
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