Hsp90 inhibitors block outgrowth of EBV-infected malignant cells in vitro and in vivo through an EBNA1-dependent mechanism

EBV causes infectious mononucleosis and is associated with certain malignancies. EBV nuclear antigen 1 (EBNA1) mediates EBV genome replication, partition, and transcription, and is essential for persistence of the viral genome in host cells. Here we demonstrate that Hsp90 inhibitors decrease EBNA1 e...

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Hauptverfasser: Sun, Xiaoping, Barlow, Elizabeth A., Ma, Shidong, Hagemeier, Stacy R., Duellman, Sarah J., Burgess, Richard R., Tellam, Judy, Khanna, Rajiv, Kenney, Shannon C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2010
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2840277/
https://ncbi.nlm.nih.gov/pubmed/20133771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0910717107
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