Sites in the AAV5 capsid tolerant to deletions and tandem duplications

Gene therapy vectors based on adeno-associated virus (AAV) have shown much promise in clinical trials for the treatment of a variety of diseases. However, the ability to manipulate and engineer the viral surface for enhanced efficiency is necessary to overcome such barriers as pre-existing immunity...

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Bibliographic Details
Main Authors: Hida, Kaoru, Won, Sang Y., Di Pasquale, Giovanni, Hanes, Justin, Chiorini, John A., Ostermeier, Marc
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2840209/
https://ncbi.nlm.nih.gov/pubmed/20102698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2010.01.009
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