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Sites in the AAV5 capsid tolerant to deletions and tandem duplications
Gene therapy vectors based on adeno-associated virus (AAV) have shown much promise in clinical trials for the treatment of a variety of diseases. However, the ability to manipulate and engineer the viral surface for enhanced efficiency is necessary to overcome such barriers as pre-existing immunity...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2010
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2840209/ https://ncbi.nlm.nih.gov/pubmed/20102698 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2010.01.009 |
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