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Islet amyloid deposition limits the viability of human islet grafts but not porcine islet grafts
Islet transplantation is a promising treatment for diabetes but long-term success is limited by progressive graft loss. Aggregates of the beta cell peptide islet amyloid polypeptide (IAPP) promote beta cell apoptosis and rapid amyloid formation occurs in transplanted islets. Porcine islets are an at...
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| Main Authors: | , , , , , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2840144/ https://ncbi.nlm.nih.gov/pubmed/20160085 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0909024107 |
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