Stem cell-specific activation of an ancestral myc protooncogene with conserved basic functions in the early metazoan Hydra

The c-myc protooncogene encodes a transcription factor (Myc) with oncogenic potential. Myc and its dimerization partner Max are bHLH-Zip DNA binding proteins controlling fundamental cellular processes. Deregulation of c-myc leads to tumorigenesis and is a hallmark of many human cancers. We have iden...

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Main Authors: Hartl, Markus, Mitterstiller, Anna-Maria, Valovka, Taras, Breuker, Kathrin, Hobmayer, Bert, Bister, Klaus
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2010
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2840113/
https://ncbi.nlm.nih.gov/pubmed/20142507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0911060107
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