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Only two amino acids are essential for cytolytic toxin recognition of cholesterol at the membrane surface

The recognition and binding of cholesterol is an important feature of many eukaryotic, viral, and prokaryotic proteins, but the molecular details of such interactions are understood only for a few proteins. The pore-forming cholesterol-dependent cytolysins (CDCs) contribute to the pathogenic mechani...

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Autors principals: Farrand, Allison J., LaChapelle, Stephanie, Hotze, Eileen M., Johnson, Arthur E., Tweten, Rodney K.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2840085/
https://ncbi.nlm.nih.gov/pubmed/20145114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0911581107
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