Amphiregulin Promotes BAX Inhibition and Resistance to Gefitinib in Non-small-cell Lung Cancers

Molecular resistance mechanisms affecting the efficiency of receptor tyrosine kinase inhibitors such as gefitinib in non-small-cell lung cancer (NSCLC) cells are not fully understood. Amphiregulin (Areg) overexpression has been proposed to predict NSCLC resistance to gefitinib and we have establishe...

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Bibliographic Details
Main Authors: Busser, Benoît, Sancey, Lucie, Josserand, Véronique, Niang, Carole, Favrot, Marie C, Coll, Jean-Luc, Hurbin, Amandine
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2009
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2839434/
https://ncbi.nlm.nih.gov/pubmed/19826406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2009.226
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