Induction of Shock After Intravenous Injection of Adenovirus Vectors: A Critical Role for Platelet-activating Factor

Innate immune responses are a major barrier to safe systemic gene therapy with adenovirus (Ad) vectors. We show that intravenous (IV) injection of rats with Ad5 vectors causes a novel rapid shock reaction that involves hypotension, hemoconcentration, tissue edema, and vasocongestion, with notable pa...

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Detalhes bibliográficos
Main Authors: Xu, Zhili, Smith, Jeffrey S., Tian, Jie, Byrnes, Andrew P.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2009
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2839431/
https://ncbi.nlm.nih.gov/pubmed/19953082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2009.279
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