Mycobacterium tuberculosis infection induces il12rb1 splicing to generate a novel IL-12Rβ1 isoform that enhances DC migration

RNA splicing is an increasingly recognized regulator of immunity. Here, we demonstrate that after Mycobacterium tuberculosis infection (mRNA) il12rb1 is spliced by dendritic cells (DCs) to form an alternative (mRNA) il12rb1Δtm that encodes the protein IL-12Rβ1ΔTM. Compared with IL-12Rβ1, IL-12Rβ1ΔTM...

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Detalhes bibliográficos
Main Authors: Robinson, Richard T., Khader, Shabaana A., Martino, Cynthia A., Fountain, Jeffrey J., Teixeira-Coelho, Maria, Pearl, John E., Smiley, Stephen T., Winslow, Gary M., Woodland, David L., Walter, Michael J., Conejo-Garcia, Jose R., Gubler, Ueli, Cooper, Andrea M.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2839154/
https://ncbi.nlm.nih.gov/pubmed/20212068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20091085
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