Upregulation of Elastase Activity in Aorta in Mucopolysaccharidosis I and VII Dogs May be Due to Increased Cytokine Expression

Mucopolysaccharidosis I (MPS I) and MPS VII are due to loss-of-function mutations within the genes that encode the lysosomal enzymes α-L-iduronidase and β-glucuronidase, respectively, and result in accumulation of glycosaminoglycans and multisystemic disease. Both disorders are associated with elast...

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Main Authors: Metcalf, Jason A., Linders, Bruce, Wu, Susan, Bigg, Paul, O’Donnell, Patricia, Sleeper, Meg M., Whyte, Michael P., Haskins, Mark, Ponder, Katherine P.
Format: Artigo
Jezik:Inglês
Izdano: 2009
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2838970/
https://ncbi.nlm.nih.gov/pubmed/20044292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymgme.2009.12.003
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