Bmp2 and Bmp4 exert opposing effects in hypoxic pulmonary hypertension

The bone morphogenetic protein (BMP) type 2 receptor ligand, Bmp2, is upregulated in the peripheral pulmonary vasculature during hypoxia-induced pulmonary hypertension (PH). This contrasts with the expression of Bmp4, which is expressed in respiratory epithelia throughout the lung. Unlike heterozygo...

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Hlavní autoři: Anderson, Lynda, Lowery, Jonathan W., Frank, David B., Novitskaya, Tatiana, Jones, Mark, Mortlock, Douglas P., Chandler, Ronald L., de Caestecker, Mark P.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2010
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2838658/
https://ncbi.nlm.nih.gov/pubmed/20042692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpregu.00534.2009
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