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Anemic Copper-Deficient Rats, but Not Mice, Display Low Hepcidin Expression and High Ferroportin Levels

The transmembrane protein ferroportin (Fpn) is essential for iron efflux from the liver, spleen, and duodenum. Fpn is regulated predominantly by the circulating iron regulatory hormone hepcidin, which binds to cell surface Fpn, initiating its degradation. Accordingly, when hepcidin concentrations de...

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Hlavní autoři: Jenkitkasemwong, Supak, Broderius, Margaret, Nam, Hyeyoung, Prohaska, Joseph R., Knutson, Mitchell D.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Nutrition 2010
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2838621/
https://ncbi.nlm.nih.gov/pubmed/20164366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3945/jn.109.117077
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