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Activation of the AMP-activated Protein Kinase – p38 MAP Kinase Pathway Mediates Apoptosis induced by Conjugated Linoleic Acid in p53-Mutant Mouse Mammary Tumor Cells

Conjugated linoleic acid (CLA) inhibits tumorigenesis and tumor growth in most model systems, an effect mediated in part by its pro-apoptotic activity. We previously showed that trans-10,cis-12 CLA induced apoptosis of p53-mutant TM4t mouse mammary tumor cells through both mitochondrial and endoplas...

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Detalhes bibliográficos
Main Authors: Hsu, Yung-Chung, Meng, Xiaojing, Ou, Lihui, Ip, Margot M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2838459/
https://ncbi.nlm.nih.gov/pubmed/19932174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2009.11.011
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