Small-molecule inhibitors target Escherichia coli amyloid biogenesis and biofilm formation

Curli are functional extracellular amyloid fibers produced by uropathogenic Escherichia coli (UPEC) and other Enterobacteriaceae. Ring-fused 2-pyridones, such as FN075 and BibC6, inhibited curli biogenesis in UPEC and prevented the in vitro polymerization of the major curli subunit protein CsgA. The...

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Autors principals: Cegelski, Lynette, Pinkner, Jerome S, Hammer, Neal D, Cusumano, Corinne K, Hung, Chia S, Chorell, Erik, Åberg, Veronica, Walker, Jennifer N, Seed, Patrick C, Almqvist, Fredrik, Chapman, Matthew R, Hultgren, Scott J
Format: Artigo
Idioma:Inglês
Publicat: 2009
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2838449/
https://ncbi.nlm.nih.gov/pubmed/19915538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.242
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