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Rationally designed small compounds inhibit pilus biogenesis in uropathogenic bacteria
A chemical synthesis platform with broad applications and flexibility was rationally designed to inhibit biogenesis of adhesive pili assembled by the chaperone–usher pathway in Gram-negative pathogens. The activity of a family of bicyclic 2-pyridones, termed pilicides, was evaluated in two different...
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| Main Authors: | , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1693844/ https://ncbi.nlm.nih.gov/pubmed/17098869 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0606795103 |
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