Rationally designed small compounds inhibit pilus biogenesis in uropathogenic bacteria

A chemical synthesis platform with broad applications and flexibility was rationally designed to inhibit biogenesis of adhesive pili assembled by the chaperone–usher pathway in Gram-negative pathogens. The activity of a family of bicyclic 2-pyridones, termed pilicides, was evaluated in two different...

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Main Authors: Pinkner, Jerome S., Remaut, Han, Buelens, Floris, Miller, Eric, Åberg, Veronica, Pemberton, Nils, Hedenström, Mattias, Larsson, Andreas, Seed, Patrick, Waksman, Gabriel, Hultgren, Scott J., Almqvist, Fredrik
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2006
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1693844/
https://ncbi.nlm.nih.gov/pubmed/17098869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0606795103
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